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1

The agarose double helix and its function in agarose gel structure

Struther Arnott, A. Fulmer, W.E. Scott, I.C.M. Dea, R. Moorhouse, D.A. Rees

Journal:

Journal of Molecular Biology

Year:

1974

Language:

english

File:

PDF, 2.09 MB

english, 1974

2

Suppression of Gonadotropins and Estradiol in Premenopausal Women by Oral Administration of the Nonpeptide Gonadotropin-Releasing Hormone Antagonist Elagolix

Struthers, R. Scott, Nicholls, Andrew J., Grundy, John, Chen, Takung, Jimenez, Roland, Yen, Samuel S. C., Bozigian, Haig P.

Journal:

Journal of Clinical Endocrinology & Metabolism

Year:

2009

Language:

english

File:

PDF, 202 KB

english, 2009

3

OR23-05 Human Absorption, Metabolism, Excretion, and Absolute Oral Bioavailability of 14C-CRN00808, an Orally Bioavailable, Nonpeptide, Selective, Somatostatin Receptor 2 (sST2) Biased Agonist for the Treatment of Acromegaly

Madan, Ajay, Luo, Rosa, Cook, Stephen Ferrara, Struthers, Scott, van Marle, Sjoerd, Krasner, Alan

Journal:

Journal of the Endocrine Society

Year:

2020

File:

PDF, 111 KB

2020

4

Extended retro-inverso analogs of somatostatin

Peter Pallai, Scott Struthers, Murray Goodman, Jean Rivier, Wylie Vale

Journal:

Year:

1983

Language:

english

File:

PDF, 925 KB

english, 1983

5

ChemInform Abstract: Design of Potent Dicyclic (4—10/5—8) Gonadotropin Releasing Hormone (GnRH) Antagonists.

Jean E. Rivier, R. Scott Struthers, John Porter, Sabine L. Lahrichi, Guangcheng Jiang, Laura A. Cervini, Michel Ibea, Dean A. Kirby, Steven C. Koerber, Catherine L. Rivier

Journal:

Year:

2000

File:

PDF, 25 KB

2000

6

ChemInform Abstract: Design of Potent Dicyclic (1—5/4—10) Gonadotropin Releasing Hormone (GnRH) Antagonists.

Jean E. Rivier, Guangcheng Jiang, R. Scott Struthers, Steven C. Koerber, John Porter, Laura A. Cervini, Dean A. Kirby, A Grey Craig, Catherine L. Rivier

Journal:

Year:

2000

File:

PDF, 25 KB

2000

7

ChemInform Abstract: Design of Monocyclic (1—3) and Dicyclic (1—3/4—10) Gonadotropin Releasing Hormone (GnRH) Antagonists.

Jean E. Rivier, John Porter, Laura A. Cervini, Sabine L. Lahrichi, Dean A. Kirby, R. Scott Struthers, Steven C. Koerber, Catherine L. Rivier

Journal:

Year:

2000

File:

PDF, 24 KB

2000

8

ChemInform Abstract: Initial Structure—Activity Relationship Studies of a Novel Series of Pyrrolo[1,2-a]pyrimid-7-ones as GnRH Receptor Antagonists.

Yun-Fei Zhu, R. Scott Struthers, Patrick J. Connors Jr., Yinghong Gao, Timothy D. Gross, John Saunders, Keith Wilcoxen, Greg J. Reinhart, Nicholas Ling, Chen Chen

Journal:

Year:

2002

File:

PDF, 34 KB

2002

9

ChemInform Abstract: Design, Synthesis and Structure—Activity Relationships of Novel Imidazolo[1,2-a]pyrimid-5-ones as Potent GnRH Receptor Antagonists.

Timothy D. Gross, Yun-Fei Zhu, John Saunders, Keith M. Wilcoxen, Yinghong Gao, Patrick J. Connors Jr., Zhiqiang Guo, R. Scott Struthers, Greg J. Reinhart, Chen Chen

Journal:

Year:

2002

File:

PDF, 29 KB

2002

10

ChemInform Abstract: Synthesis and Initial Structure—Activity Relationships of a Novel Series of Imidazolo[1,2-a]pyrimid-5-ones as Potent GnRH Receptor Antagonists

Keith M. Wilcoxen, Yun-Fei Zhu, Patrick J. Connors Jr., John Saunders, Timothy D. Gross, Yinghong Gao, Greg J. Reinhart, R. Scott Struthers, Chen Chen

Journal:

Year:

2002

File:

PDF, 34 KB

2002

11

A Novel Synthesis of 7-Aryl-8-fluoro-pyrrolo[1,2-a]pyrimid-4-ones as Potent, Stable GnRH Receptor Antagonists.

Fabio C. Tucci, Yun-Fei Zhu, Zhiqiang Guo, Timothy D. Gross, Patrick J. Connors Jr., R. Scott Struthers, Greg J. Reinhart, Xiaochuan Wang, John Saunders, Chen Chen

Journal:

Year:

2003

File:

PDF, 126 KB

2003

12

Synthesis and Structure—Activity Relationships of 1-Arylmethyl-3-(2-aminopropyl)-5-aryl-6-methyluracils as Potent GnRH Receptor Antagonists.

Zhiqiang Guo, Yun-Fei Zhu, Fabio C. Tucci, Yinghong Gao, R. Scott Struthers, John Saunders, Timothy D. Gross, Qiu Xie, Greg J. Reinhart, Chen Chen

Journal:

Year:

2004

File:

PDF, 98 KB

2004

13

Synthesis and Structure—Activity Relationships of Thieno[2,3-d]pyrimidine-2,4-dione Derivatives as Potent GnRH Receptor Antagonists.

Zhiqiang Guo, Yongsheng Chen, Dongpei Wu, Yun-Fei Zhu, R. Scott Struthers, John Saunders, Qiu Xie, Chen Chen

Journal:

Year:

2004

File:

PDF, 92 KB

2004

14

Synthesis and Structure—Activity Relationships of (R)-1-Alkyl-3-[2-(2-amino)phenethyl]-5-(2-fluorophenyl)-6-methyluracils as Human GnRH Receptor Antagonists.

Martin W. Rowbottom, Fabio C. Tucci, Yun-Fei Zhu, Zhiqiang Guo, Timothy D. Gross, Greg J. Reinhart, Qui Xie, R. Scott Struthers, John Saunders, Chen Chen

Journal:

Year:

2004

File:

PDF, 102 KB

2004

15

A Convenient One-Pot Synthesis of Asymmetric 1,3,5-Triazine-2,4,6-triones and Its Application Towards a Novel Class of Gonadotropin-Releasing Hormone Receptor Antagonists.

Zhiqiang Guo, Dongpei Wu, Yun-Fei Zhu, Fabio C. Tucci, Joseph Pontillo, John Saunders, Qiu Xie, R. Scott Struthers, Chen Chen

Journal:

Year:

2005

File:

PDF, 22 KB

2005

16

Atropisomeric property of 1-(2,6-difluorobenzyl)-3-[(2R)-amino-2-phenethyl]-5-(2-fluoro-3-methoxyphenyl)-6-methyluracil

Fabio C. Tucci, Tao Hu, Michael F. Mesleh, Allan Bokser, Eric Allsopp, Timothy D. Gross, Zhiqiang Guo, Yun-Fei Zhu, R. Scott Struthers, Nicholas Ling, Chen Chen

Journal:

Year:

2005

Language:

english

File:

PDF, 227 KB

english, 2005

17

Development of an advanced modelling environment

P.Z. Maguire, D.M. Scott, W.R. Paterson, A. Struthers

Journal:

Computers & Chemical Engineering

Year:

1995

Language:

english

File:

PDF, 695 KB

english, 1995

18

A convenient one-pot synthesis of asymmetric 1,3,5-triazine-2,4,6-triones and its application towards a novel class of gonadotropin-releasing hormone receptor antagonists

Zhiqiang Guo, Dongpei Wu, Yun-Fei Zhu, Fabio C. Tucci, Joseph Pontillo, John Saunders, Qiu Xie, R. Scott Struthers, Chen Chen

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2005

Language:

english

File:

PDF, 352 KB

english, 2005

19

Identification of 2-(4,5,6,7-tetrahydro-1H-pyrrolo[3,2-c]pyridin-3-yl)-ethylamine derivatives as novel GnRH receptor antagonists

Mi Chen, Zhiqiang Guo, Marion C. Lanier, Liren Zhao, Stephen F. Betz, Charles Q. Huang, Colin J. Loweth, Neil J. Ashweek, Xin-Jun Liu, R. Scott Struthers, Margaret J. Bradbury, James W. Behan, Jenny W

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2007

Language:

english

File:

PDF, 175 KB

english, 2007

20

Uracils as potent antagonists of the human gonadotropin-releasing hormone receptor without atropisomers

Zhiqiang Guo, Yongsheng Chen, Charles Q. Huang, Timothy D. Gross, Joseph Pontillo, Martin W. Rowbottom, John Saunders, Scott Struthers, Fabio C. Tucci, Qiu Xie, Warren Wade, Yun-Fei Zhu, Dongpei Wu, C

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2005

Language:

english

File:

PDF, 144 KB

english, 2005

21

5-Aryluracils as potent GnRH antagonists—Characterization of atropisomers

Liren Zhao, Zhiqiang Guo, Yongsheng Chen, Tao Hu, Dongpei Wu, Yun-Fei Zhu, Martin Rowbottom, Timothy D. Gross, Fabio C. Tucci, R. Scott Struthers, Qiu Xie, Chen Chen

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2008

Language:

english

File:

PDF, 217 KB

english, 2008

22

Zwitterionic uracil derivatives as potent GnRH receptor antagonists with improved pharmaceutical properties

Colin F. Regan, Zhiqiang Guo, Yongsheng Chen, Charles Q. Huang, Mi Chen, Wanlong Jiang, Jaimie K. Rueter, Timothy Coon, Chen Chen, John Saunders, Michael S. Brown, Steve F. Betz, R. Scott Struthers, C

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2008

Language:

english

File:

PDF, 185 KB

english, 2008

23

Effects of Imagent® on pulmonary hemodynamics and gas exchange in dogs

Scott D. Kirkton, Harrieth Wagner, Maria M. Landicho, Jeff J. Struthers, Nicholas Busan, Peter D. Wagner

Journal:

Ultrasound in Medicine & Biology

Year:

2006

Language:

english

File:

PDF, 439 KB

english, 2006

24

The use of agents both to represent and to implement process engineering models

P.Z. Maguire, A. Struthers, D.M. Scott, W.R. Paterson

Journal:

Computers & Chemical Engineering

Year:

1998

Language:

english

File:

PDF, 923 KB

english, 1998

25

Initial Structure–Activity Relationship Studies of a Novel Series of Pyrrolo[1,2-a]pyrimid-7-ones as GnRH Receptor Antagonists

Yun-Fei Zhu, R.Scott Struthers, Patrick J. Connors, Jr., Yinghong Gao, Timothy D. Gross, John Saunders, Keith Wilcoxen, Greg J. Reinhart, Nicholas Ling, Chen Chen

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2002

Language:

english

File:

PDF, 121 KB

english, 2002

26

A Novel Synthesis of 2-Arylpyrrolo[1,2-a]pyrimid-7-ones and Their Structure–Activity Relationships as Potent GnRH Receptor Antagonists

Yun-Fei Zhu, Keith Wilcoxen, John Saunders, Zhiqiang Guo, Yinghong Gao, Patrick J. Connors, Jr., Timothy D. Gross, Fabio C. Tucci, R. Scott Struthers, Greg J. Reinhart, Qiu Xie, Chen Chen

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2002

Language:

english

File:

PDF, 122 KB

english, 2002

27

Design, synthesis and structure–Activity relationships of novel imidazolo[1,2-a]pyrimid-5-ones as potent GnRH receptor antagonists

Timothy D. Gross, Yun-Fei Zhu, John Saunders, Keith M. Wilcoxen, Yinghong Gao, Patrick J. Connors Jr., Zhiqiang Guo, R.Scott Struthers, Greg J. Reinhart, Chen Chen

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2002

Language:

english

File:

PDF, 105 KB

english, 2002

28

A novel synthesis of 7-aryl-8-fluoro-pyrrolo[1,2-a]pyrimid-4-ones as potent, stable GnRH receptor antagonists

Fabio C. Tucci, Yun-Fei Zhu, Zhiqiang Guo, Timothy D. Gross, Patrick J. Connors Jr., R.Scott Struthers, Greg J. Reinhart, Xiaochuan Wang, John Saunders, Chen Chen

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2002

Language:

english

File:

PDF, 253 KB

english, 2002

29

Synthesis and Structure–activity relationships of 1-arylmethyl-3-(1-methyl-2-amino)ethyl-5-aryl-6-methyluracils as antagonists of the human GnRH Receptor

Fabio C. Tucci, Yun-Fei Zhu, Zhiqiang Guo, Timothy D. Gross, Patrick J. Connors Jr., R.Scott Struthers, Greg J. Reinhart, John Saunders, Chen Chen

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2003

Language:

english

File:

PDF, 214 KB

english, 2003

30

Synthesis and Structure–Activity relationships of 1-arylmethyl-3-(2-aminopropyl)-5-aryl-6-methyluracils as potent GnRH receptor antagonists

Zhiqiang Guo, Yun-Fei Zhu, Fabio C. Tucci, Yinghong Gao, R.Scott Struthers, John Saunders, Timothy D. Gross, Qiu Xie, Greg J. Reinhart, Chen Chen

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2003

Language:

english

File:

PDF, 192 KB

english, 2003

31

Synthesis and structure–Activity relationships of thieno[2,3-d]pyrimidine-2,4-dione derivatives as potent GnRH receptor antagonists

Zhiqiang Guo, Yongsheng Chen, Dongpei Wu, Yun-Fei Zhu, R.Scott Struthers, John Saunders, Qiu Xie, Chen Chen

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2003

Language:

english

File:

PDF, 221 KB

english, 2003

32

Design of biologically active, conformationally constrained GnRH antagonists

R. Scott Struthers, Genzo Tanaka, Steven C. Koerber, Tom Solmajer, Edmund L. Baniak, Lila M. Gierasch, Wylie Vale, Jean Rivier, Dr. Arnold T. Hagler

Journal:

Proteins: Structure, Function, and Bioinformatics

Year:

1990

Language:

english

File:

PDF, 1.19 MB

english, 1990

33

Predicted three-dimensional structure of the protease inhibitor domain of the Alzheimer's disease β-amyloid precursor

R. Scott Struthers, David H. Kitson, Arnold T. Hagler

Journal:

Proteins: Structure, Function, and Bioinformatics

Year:

1991

Language:

english

File:

PDF, 1.12 MB

english, 1991

34

The assessment of radiological changes in the hands and wrists in rheumatoid arthritis

K. A. Grindulis, D. L. Scott, G. R. Struthers

Journal:

Rheumatology International

Year:

1983

Language:

english

File:

PDF, 341 KB

english, 1983

35

Smoking and rheumatoid vasculitis

G. R. Struthers, D. L. Scott, J. P. Delamere, H. Sheppeard, M. Kitt

Journal:

Rheumatology International

Year:

1981

Language:

english

File:

PDF, 104 KB

english, 1981

36

The use of ‘Alternative treatments’ by patients with rheumatoid arthritis

G. R. Struthers, D. L. Scott

Journal:

Rheumatology International

Year:

1983

Language:

english

File:

PDF, 163 KB

english, 1983

37

Septic arthritis and thigh abscess after dilatation and curettage

G. R. Struthers, D. L. Scott, M. Farr

Journal:

Clinical Rheumatology

Year:

1984

Language:

english

File:

PDF, 279 KB

english, 1984

38

Synthesis and structure–activity relationships of (R)-1-alkyl-3-[2-(2-amino)phenethyl]-5-(2-fluorophenyl)-6-methyluracils as human GnRH receptor antagonists

Martin W Rowbottom, Fabio C Tucci, Yun-Fei Zhu, Zhiqiang Guo, Timothy D Gross, Greg J Reinhart, Qui Xie, R.Scott Struthers, John Saunders, Chen Chen

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2004

Language:

english

File:

PDF, 281 KB

english, 2004

39

Structure–activity relationships of 1,3,5-triazine-2,4,6-triones as human gonadotropin-releasing hormone receptor antagonists

Zhiqiang Guo, Dongpei Wu, Yun-Fei Zhu, Fabio C. Tucci, Collin F. Regan, Martin W. Rowbottom, R. Scott Struthers, Qiu Xie, Shelby Reijmers, Susan K. Sullivan, Yang Sai, Chen Chen

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2005

Language:

english

File:

PDF, 259 KB

english, 2005

40

Synthesis of aryl-1,2,4-triazine-3,5-diones as antagonists of the gonadotropin-releasing hormone receptor

Joseph Pontillo, Zhiqiang Guo, Dongpei Wu, R. Scott Struthers, Chen Chen

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2005

Language:

english

File:

PDF, 205 KB

english, 2005

41

Synthesis and initial structure–Activity relationships of a novel series of imidazolo[1,2-a]pyrimid-5-ones as potent GnRH receptor antagonists

Keith M. Wilcoxen, Yun-Fei Zhu, Patrick J. Connors Jr., John Saunders, Timothy D. Gross, Yinghong Gao, Greg J. Reinhart, R.Scott Struthers, Chen Chen

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2002

Language:

english

File:

PDF, 140 KB

english, 2002

42

Somatotroph hypoplasia and dwarfism in transgenic mice expressing a non-phosphorylatable CREB mutant

Struthers, R. Scott, Vale, Wylie W., Arias, Carlos, Sawchenko, Paul E., Montminy, Marc R.

Journal:

Year:

1991

File:

PDF, 892 KB

1991

43

Immunoglobulin-producing cells in labial salivary glands of patients with rheumatoid arthritis and systemic lupus erythematosus

J. B. Matthews, A. J. C. Potts, J. Hamburger, G. Struthers, D. G. I. Scott

Journal:

Journal of Oral Pathology & Medicine

Year:

1986

Language:

english

File:

PDF, 409 KB

english, 1986

44

A Screening Library for Peptide Activated G-Protein Coupled Receptors. 1. The Test Set

Lavrador, Karine, Murphy, Brian, Saunders, John, Struthers, Scott, Wang, Xiaochuan, Williams, John

Journal:

Journal of Medicinal Chemistry

Year:

2004

Language:

english

File:

PDF, 391 KB

english, 2004

45

Kinetics of nonpeptide antagonist binding to the human gonadotropin-releasing hormone receptor: Implications for structure–activity relationships and insurmountable antagonism

Susan K. Sullivan, Sam R.J. Hoare, Beth A. Fleck, Yun-Fei Zhu, Christopher E. Heise, R. Scott Struthers, Paul D. Crowe

Journal:

Biochemical Pharmacology

Year:

2006

Language:

english

File:

PDF, 655 KB

english, 2006

46

A high-throughput chemotaxis assay for pharmacological characterization of chemokine receptors: Utilization of U937 monocytic cells

Thomas R. Ott, Anil Pahuja, Francisco M. Lio, Monica S. Mistry, Molly Gross, Sarah C. Hudson, Warren S. Wade, Pedro B. Simpson, R. Scott Struthers, David G. Alleva

Journal:

Journal of Pharmacological and Toxicological Methods

Year:

2005

Language:

english

File:

PDF, 353 KB

english, 2005

47

The N-terminal domain of CCL21 reconstitutes high affinity binding, G protein activation, and chemotactic activity, to the C-terminal domain of CCL19

Thomas R. Ott, Francisco M. Lio, Dennis Olshefski, Xin-Jun Liu, Nicholas Ling, R. Scott Struthers

Journal:

Biochemical and Biophysical Research Communications

Year:

2006

Language:

english

File:

PDF, 207 KB

english, 2006

48

Cellular levels of the syntaxin Tlg2p are regulated by a single mode of binding to Vps45p

Lindsay N. Carpp, Scott G. Shanks, Marion S. Struthers, Nia J. Bryant

Journal:

Biochemical and Biophysical Research Communications

Year:

2007

Language:

english

File:

PDF, 200 KB

english, 2007

49

3-(2-Aminoalkyl)-1-(2,6-difluorobenzyl)-5- (2-fluoro-3-methoxyphenyl)-6-methyl- uracils as Orally Bioavailable Antagonists of the Human Gonadotropin Releasing Hormone Receptor

Tucci, Fabio C., Zhu, Yun-Fei, Guo, Zhiqiang, Gross, Timothy D., Connors,, Patrick J., Gao, Yinghong, Rowbottom, Martin W., Struthers, R. Scott, Reinhart, Greg J., Xie, Qiu, Chen, Ta Kung, Bozigian, H

Journal:

Journal of Medicinal Chemistry

Year:

2004

Language:

english

File:

PDF, 67 KB

english, 2004

50

Synthesis and Structure−Activity Relationships of 1-Arylmethyl-5-aryl-6-methyluracils as Potent Gonadotropin-Releasing Hormone Receptor Antagonists

Guo, Zhiqiang, Zhu, Yun-Fei, Gross, Timothy D., Tucci, Fabio C., Gao, Yinghong, Moorjani, Manisha, Connors,, Patrick J., Rowbottom, Martin W., Chen, Yongsheng, Struthers, R. Scott, Xie, Qiu, Saunders,

Journal:

Journal of Medicinal Chemistry

Year:

2004

Language:

english

File:

PDF, 229 KB

english, 2004

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